The figure reports the JASPAR PWM associated with the TF (the version with best accuracy if several versions are available) and different plots related to the sHMM and the identified tracks.
Fig. A
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When the PWM is known, the A plot reports the AUROC achieved by the PWM and the sHMM, followed by the sHMM AUROC when removing the PWM effect (adjusted-AUROC, HMM/P), the adjusted-AUROC when the PWM score is low (Q1) and the adjusted-AUROC when the PWM score is high (Q2).
Fig. B
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Plot B reports the nucleotidic distribution of the state modelling the tracks (for three-states sHMMs), or of the gap-state (for k-mer sHMMs).
Fig. C
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Plot C is the sHMM ROC.
Fig. D
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Plot D reports the length distribution of the identified tracks on positive and negative sequences.
Fig. E-F
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Plot E-F report the distribution of the number of k-mer occurrences and gap proportion for k-mer sHMMs.
Fig. G
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Plot G reports the coverage of the identified tracks on positive and negative sequences, i.e., for each nucleotide position, the proportion of sequences covered by the track at this position. This plot also shows the expected coverages that would be obtained if the identified tracks were uniformly distributed on the sequences.
Fig. H
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Plot H is a representation of the different tracks identified on the sequences. Tracks closer to the 5' end (resp. 3' end) are on the upper (resp. lower) part of the plot. For each set (5' or 3') tracks are drawn from the longest to the smallest, starting from the median line toward the top (5') or the bottom (3') of the plot.
Fig. I
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Plot I shows the AUROC of the selected sHMMs along those of the 10 most common sHMMs of the library. For ST library, sHMMs with a positional bias toward the center of the peaks appear in black.
Tip: use the arrow keys to move between experiments.